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Certain medications, supplements and/or foods may impact test results. Please note that the reference ranges were not established based on patients taking any medications or supplements. In some instances it is unknown what potential impact a medication may have on test results.
Genova never recommends that patients discontinue medically necessary medications or supplements in order to complete testing. There may be times when a patient may stay on a medication or dietary supplement during testing in order to evaluate its effectiveness. The recommendation to discontinue any substance is intended to establish a baseline finding.
Below you will find a list detailing potential interference or influence of certain substances on the biomarkers:
|Kit Instruction||Recommended Timeframe to Discontinue||Possible Biomarker(s) Impacted|
|It is recommended to eat your usual diet during collection|
|High protein||No recommendation to discontinue if this is the usual diet||May see elevated putrefactive SCFAs|
|High fat||May see elevated fecal fats|
|Foods with beneficial flora added (i.e. Activia® yogurt)||14 days||May influence the beneficial bacteria levels on culture, as well as metabolic markers; the presence of beneficial bacteria may alter levels of other bacteria, yeast and parasites|
|Anti-inflammatory and Immune Modulating Medications|
|Aspirin and NSAIDs (i.e. ibuprofen, etc.)||2 days||May influence inflammation/immune biomarkers (EPX, calprotectin)|
|Steroid (i.e. prednisone, etc.)||No recommendation to discontinue|
|Autoimmune medications (i.e. Humira, etc.)|
|Digestive Tract Medications and Supplements|
|Probiotics (beneficial bacteria)||14 days||May influence the beneficial bacteria levels on culture, as well as metabolic markers; the presence of beneficial bacteria may alter levels of other bacteria, yeast and parasites|
|Antacids (i.e. proton-pump inhibitors)||3-14 days; if ordering the H pylori add-on, 14 days is recommended||May result in false negative H. pylori if PPI not discontinued for 14 days (H2 blockers do not interfere); additionally, acid-blocking medication may influence levels of the digestion and absorption markers; PPIs may clear the body relatively quickly, however the antacid effect may linger 3-5 days|
|Bismuth||2 days; if ordering the H pylori add-on, 14 days is recommended||May result in false negative H. pylori if bismuth not discontinued for 14 days; may affect other bacterial levels|
|Antacids (i.e. Tums, Rolaids, H2 blockers)||2 days||Acid-blocking medication may influence levels of the digestion and absorption markers|
|Bentonite clay||Bentonite clay affects bacteria and parasites that may be identified through microscopic examination and culture growth|
|Betaine HCl||Hydrochloric acid is intended to improve digestion, therefore markers of digestion and absorption may be influenced|
|Digestive enzymes||Enzymes are intended to improve digestion, therefore markers of digestion and absorption may be influenced|
|Laxatives||Laxatives are intended to alter transit time; if laxative use results in normalized transit, there may be no effect on biomarkers; however if transit time is rapid, the markers of digestion and absorption may be influenced|
|Mineral oil, castor oil|
|Activated charcoal||Activated charcoal can make identification of organisms seen in culture and microscopic examination more difficult|
|Rectal suppositories, enemas||These agents can alter the density of stool samples resulting in inaccurate biomarker findings|
|Please note that 4 weeks is recommended from colonoscopy or barium enema before beginning the test. It has been observed that 4 weeks is sufficient time for most patients to resume their previous level of gut function, considering elimination of all traces of barium, dietary/digestive normalization and re-generation of microflora populations.|
(28 days may be preferred after antibiotics)
|May influence levels of bacteria, yeast and parasites, as well as metabolic markers|
We do not generally recommend stool testing in children under the age of two as they are still establishing their gut flora which can impact numerous findings on the test. Inflammatory markers, such as Calprotectin, can also be skewed in younger children, especially if they are still breastfeeding. Reference ranges for many of the markers have not been established for this population.More Info – CDSA Test Order Page
Certain medications, supplements and/or foods may impact test results.
Please consult with your healthcare provider before stopping any prescription or over-the-counter medications or dietary supplements. Genova never recommends that patients discontinue medically necessary medications or supplements in order to complete testing.
There may be times when your healthcare provider prefers that you stay on a medication or dietary supplement during testing in order to evaluate its effectiveness.
The test is not recommended for patients under 2 years of age.
We do not suggest collecting during an acute gastrointestinal infectious illness.
Discontinue all of the following (unless instructed otherwise by your physician).
Storing your samples: Send in your samples as soon as you complete the test. Refrigerate samples until shipping. Do NOT freeze.
Plan for Monday–Friday collection only: Specimens must be received in the laboratory within 4 days of Day 3 collection. If you take the test over the weekend, call FedEx to schedule a pick-up on Monday.
Contact FedEx and schedule to ship the specimen overnight delivery Monday–Friday.More Info – CDSA Test Order Page