CDSA Test Prep

Comprehensive Digestive Stool Analysis™


Instructions for Clinicians and Patients


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 — CLINICIANS — 

Important Prep Before Patient Takes Test

Certain medications, supplements and/or foods may impact test results. Please note that the reference ranges were not established based on patients taking any medications or supplements. In some instances it is unknown what potential impact a medication may have on test results.

Genova never recommends that patients discontinue medically necessary medications or supplements in order to complete testing. There may be times when a patient may stay on a medication or dietary supplement during testing in order to evaluate its effectiveness. The recommendation to discontinue any substance is intended to establish a baseline finding.

Below you will find a list detailing potential interference or influence of certain substances on the biomarkers:

Kit Instruction Recommended Timeframe to Discontinue Possible Biomarker(s) Impacted
Dietary Factors
It is recommended to eat your usual diet during collection
High protein

No recommendation to discontinue if this is the usual diet May see elevated putrefactive SCFAs
High fat May see elevated fecal fats
Foods with beneficial flora added (i.e. Activia® yogurt) 14 days May influence the beneficial bacteria levels on culture, as well as metabolic markers; the presence of beneficial bacteria may alter levels of other bacteria, yeast and parasites

Anti-inflammatory and Immune Modulating Medications
Aspirin and NSAIDs (i.e. ibuprofen, etc.) 2 days May influence inflammation/immune biomarkers (EPX, calprotectin)
Steroid (i.e. prednisone, etc.) No recommendation to discontinue
Autoimmune medications (i.e. Humira, etc.)
Digestive Tract Medications and Supplements
Probiotics (beneficial bacteria) 14 days May influence the beneficial bacteria levels on culture, as well as metabolic markers; the presence of beneficial bacteria may alter levels of other bacteria, yeast and parasites
Antacids (i.e. proton-pump inhibitors) 3-14 days; if ordering the H pylori add-on, 14 days is recommended May result in false negative H. pylori if PPI not discontinued for 14 days (H2 blockers do not interfere); additionally, acid-blocking medication may influence levels of the digestion and absorption markers; PPIs may clear the body relatively quickly, however the antacid effect may linger 3-5 days
Bismuth 2 days; if ordering the H pylori add-on, 14 days is recommended May result in false negative H. pylori if bismuth not discontinued for 14 days; may affect other bacterial levels
Antacids (i.e. Tums, Rolaids, H2 blockers) 2 days Acid-blocking medication may influence levels of the digestion and absorption markers
Bentonite clay Bentonite clay affects bacteria and parasites that may be identified through microscopic examination and culture growth
Betaine HCl Hydrochloric acid is intended to improve digestion, therefore markers of digestion and absorption may be influenced
Digestive enzymes

Enzymes are intended to improve digestion, therefore markers of digestion and absorption may be influenced
Laxatives

Laxatives are intended to alter transit time; if laxative use results in normalized transit, there may be no effect on biomarkers; however if transit time is rapid, the markers of digestion and absorption may be influenced
Mineral oil, castor oil
Activated charcoal Activated charcoal can make identification of organisms seen in culture and microscopic examination more difficult
Rectal suppositories, enemas These agents can alter the density of stool samples resulting in inaccurate biomarker findings
Please note that 4 weeks is recommended from colonoscopy or barium enema before beginning the test. It has been observed that 4 weeks is sufficient time for most patients to resume their previous level of gut function, considering elimination of all traces of barium, dietary/digestive normalization and re-generation of microflora populations.
Antimicrobial Agents
Antibiotics 14 days
(28 days may be preferred after antibiotics)
May influence levels of bacteria, yeast and parasites, as well as metabolic markers
Antifungals
Antiparasitics

 — CLINICIANS — 

Pediatric Patients

We do not generally recommend stool testing in children under the age of two as they are still establishing their gut flora which can impact numerous findings on the test. Inflammatory markers, such as Calprotectin, can also be skewed in younger children, especially if they are still breastfeeding. Reference ranges for many of the markers have not been established for this population.

More Info – CDSA Test Order Page

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 — PATIENTS — 

Important Prep Before Patient Takes Test

Certain medications, supplements and/or foods may impact test results.

Please consult with your healthcare provider before stopping any prescription or over-the-counter medications or dietary supplements. Genova never recommends that patients discontinue medically necessary medications or supplements in order to complete testing.

There may be times when your healthcare provider prefers that you stay on a medication or dietary supplement during testing in order to evaluate its effectiveness.

The test is not recommended for patients under 2 years of age.

We do not suggest collecting during an acute gastrointestinal infectious illness.

2–4 Weeks Before The Test

  • Wait at least 4 weeks from colonoscopy or barium enema before beginning the test
  • If taking antibiotics, antiparasitics, antifungals, probiotic supplements (acidophilus, etc.), or consuming food products containing beneficial flora (e.g. Activia®), it is recommended that you wait a minimum of 14 days after your last dose before beginning the test; 28 days may be preferred after antibiotics have been utilized
  • For H. pylori add-on testing, discontinuation of PPIs and bismuth for 14 days is recommended
 — PATIENTS — 

2 Days Before The Test

Discontinue all of the following (unless instructed otherwise by your physician).

  • The following substances should be discontinued 2 days prior unless directed otherwise by your physician: aspirin and other NSAIDs (i.e. ibuprofen), rectal suppositories, enemas, activated charcoal, bismuth, betaine HCl, digestive enzymes, antacids, laxatives, mineral oil, castor oil, and bentonite clay
  • Eat your usual diet during the 2–3 days prior to the stool collection. Contact your healthcare provider with any questions.

Plan for Monday–Friday collection only: Specimens must be received in the laboratory within 4 days of Day 3 collection. If you take the test over the weekend, call FedEx to schedule a pick-up on Monday.

Contact FedEx and schedule to ship the specimen overnight delivery Monday–Friday.

More Info – CDSA Test Order Page

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