The Genova Diagnostics Calprotectin gastrointestinal test is highly sensitive for evaluating inflammation within the gastrointestinal tract. The United States Food and Drug Administration (FDA) cleared calprotectin as a marker intended for differentiating Irritable Bowel Syndrome (IBS) from Inflammatory Bowel Disease (IBD). Calprotectin is the non-invasive gold standard for assessment of gastrointestinal inflammation and as such, is a useful clinical tool for identifying patients who warrant further GI evaluation.

Fecal calprotectin is a simple, reliable, noninvasive marker that can be used as often as needed for the following clinical uses:

  • Distinguishing between patients with Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD) with a 99% Positive Predictive Value in patients with Rome Criteria and negative calprotectin (<50 ug/g)
  • Determining disease activity and risk of relapse in IBD while assessing the level of mucosal healing
  • Assisting in the selection of patients with abdominal symptoms who may require further diagnostic procedures
  • Selecting patients for endoscopy as well as monitoring the response to treatment.┬áThis is especially useful for children, who may require general anesthesia to undergo more invasive analysis.
  • Predicting relapse in patients with IBD, allowing an objective marker to decide when to treat

Calprotectin plays a regulatory role in the inflammatory process. It is released into the intestinal lumen during activation and cell death. Calprotectin comprises approximately 60% of the cytosolic protein in neutrophils, reflecting the flux of leukocytes into the intestinal lumen.
Emerging Studies on Calprotectin:

  • Recent research highlights the role of calprotectin as an effective biomarker of mucosal healing
  • Early trials indicate the value of calprotectin in correlating with endoscopy to predict relapse, define treatment response, and confirm clinical remission

Test Type:Stool Test


  • Calprotectin


  •  Calprotectin83993  

Specimen Requirements:  10ml stool

Turn Around Time: 

7 Days

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