Gut Immunology

Why Use the Gut Immunology Test?

The Gut Immunology test measures two key biomarkers for gastrointestinal (GI) inflammation and immunology, providing information about the GI tract's interactions with, and responses to, the outside world. They indicate how well the GI tract is maintaining its role as a barrier, as well as whether the GI tract is undergoing negative responses to external or internal challenges. Interactions between the immune system and the GI tract are being recognized as of growing importance, not only in GI function and health, but also in their influences on overall health.

Evaluation of the complementary biomarkers, eosinophil protein X (EPX) and calprotectin, offers clinicians key information regarding the immune responses in the gut, and can also be used to monitor patient response to therapies.

Effective for Patients Experiencing:

  • Diarrhea
  • Cramps
  • Nausea
  • Fever
  • Vomiting
  • Fatigue
  • Symptoms meeting the conditions for Irritable Bowel Syndrome (IBS) such as:
    • Recurrent abdominal pain or discomfort
    • Change in stool frequency
    • Change in stool form
  • Food sensitivity
  • Inflammatory Bowel Disease (IBD)

About the Gut Immunology Test:

Using a simple, in-home stool collection, the Gut Immunology test evaluates the immune response in the gut by measuring two biomarkers, calprotectin and eosinophil protein X (EPX). Calprotectin is highly sensitive for evaluating inflammation within the gastrointestinal tract and for making the distinction between IBS and IBD. EPX is released as part of the immune response resulting from damage to the gut lining, such as can occur in response to a food allergen.

Test Type: Stool Test

Analyte List
Eosinophil Protein X (EPX)
Stool weight
CPT Codes  
Calprotectin 83993
Eosinophil Protein X (EPX) 83520
Specimen Requirements
40ml Stool in white top cup (for Add-ons)