Helicobacter pylori Stool Antigen EIA

A stand-alone test that can be added onto the Gastrointestinal line of tests.

Non-invasive Assay

Stool antigen tests have been recommended by both the American Gastroenterological Association (AGA) and the American College of Gastroenterologists (ACG) as the most accurate non-invasive tests for diagnosis and for confirmation of eradication.1,2 This method is highly sensitive and specific and useful for diagnosis, therapeutic monitoring, and test of eradication.

Unlike stool antigen tests, Serology-based methods have a sensitivity and specificity of only 90% and cannot distinguish between active and resolved infection.3,4 Thus, serology tests are not recommended by the AGA for initial diagnosis of H pylori infection.4 Furthermore, they are not recommended by either the AGA or the ACG for monitoring infection or confirming eradication of the organism.3,4


Is incompletely characterized. Person-to-person transmission is most commonly implicated with fecal/oral, oral/oral, or gastric/oral pathways.


Acute gastritis with abdominal pain, nausea, and vomiting. Non-ulcer dyspepsia is common. Development of severe H. pylori disease is partially determined by the virulence of the infecting strain.

Therapeutic Considerations

Conventional recommendation is polypharmacy: antibiotics and proton-pump inhibitors (PPIs). See www.acg.gi.org.

Botanical anti-H. pylori formulas may prove helpful. See www.cdc.gov/ulcer/keytocure.htm.

Test Type: StoolTest

1)Talley NJ; American Gastroenterological Association. American Gastroenterological Association medical position statement: evaluation of dyspepsia. Gastroenterology. 2005;129:1753-1755.

2) Chey WD, Wong BC; Practice Parameters Committee of the American College of Gastroenterology. American College of Gastroenterology guideline on the management of Helicobacter pylori infection. Am J Gastroenterol. 2007;102:1808-1825.

3)Talley NJ, Vakil N; Practice Parameters Committee of the American College of Gastroenterology. Guidelines for the management of dyspepsia. Am J Gastroenterol. 2005;100:2324-2337.

4)Talley NJ, Vakil NB, Moayyedi P. American Gastroenterological Association technical review on the evaluation of dyspepsia. Gastroenterology. 2005;129:1756-1780.

Analyte List
Helicobacter pylori (HpSA)
CPT Codes  
Helicobacter pylori (HpSA) 87338
Specimen Requirements