The Metabolomix+ is a unique combination of nutritional tests that provides an analysis of key nutritional biomarkers. A first morning void (FMV) urine collection, with optional add-on bloodspot finger stick and buccal swab, the Metabolomix+ nutritional test is a non-invasive, patient-friendly way to assess the functional need for antioxidants, B-vitamins, minerals, digestive support, fatty acids, and amino acids. Insights gained from the Metabolomix+ nutritional test allows clinicians to target nutritional therapies to meet the precise needs of their patients.
Metabolomix+ is one of the most comprehensive functional and nutritional assessments available. It is designed to help practitioners identify root causes of dysfunction and provide a systems-based approach to help patients overcome chronic conditions and live a healthier life.
The Metabolomix+ report offers:
Marked accumulation of organic acids in urine can signal a metabolic inhibition or block. The metabolic block may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up, or drug effect.
Enzymes that are responsible for metabolizing organic acids are vitamin and mineral dependent. With this, elevations in organic acids can reflect a functional need for these nutrients on a cellular and biochemical level, even despite normal serum levels.1-5 Recommendations for nutrient supplementation based on elevated organic acid results are generated using a literature-based proprietary algorithm.
Traditionally, urinary organic acid assessment has been used in neonatal/pediatric medicine to identify genetic inborn errors of metabolism, with severity depending on the degree and type of error.* In many cases of genetic inborn errors, the enzymatic defect may be compensated for by high doses of specific vitamin and mineral cofactors and/or dietary interventions. Intervention with higher-dose nutrient cofactors may also be effective in cases of decreased enzyme activity due to causes other than frank inborn errors.
* Genova's organic acid testing is not intended for the diagnosis of neonatal inborn errors of metabolism.Several diseases are associated with abnormal organic acid, amino acid, and fatty acid levels such as depression, anxiety, cardiovascular disease, neurocognitive decline, diabetes, cancer, anorexia, and many others.12-15
The Metabolomix+ Profile report allows for easy interpretation and clinically actionable results. It includes a Suggested Supplement Schedule that provides personalized recommendations based on test results. The Interpretation-At-A-Glance section of the report provides facts related to nutrient function, causes and complications of their deficiencies, and dietary sources.
COMPONENTS
+ COMPONENTS
Urinary organic and amino acids are measured via GCMS, LC/MS/MS and alkaline picrate. Fatty acids are measured via GCMS. Urinary oxidative stress markers are measured using colorimetric, thiobarbituric acid reactive substances (TBARS) and LC/MS/MS. Nutrient and toxic elements are measured using ICP-MS and Kinetic (Jaffe). Reference ranges are age and gender specific and are based on a questionnaire-qualified healthy cohort. Testing is not performed in patients under 2 years old.
Test Type: Urine Test
Add-Ons: Urine, Bloodspot, & Buccal Swab
Turnaround Time: 14 Days
Analyte List |
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1-Methylhistidine |
2-Hydroxyphenylacetic Acid |
3-Hydroxyproprionic Acid |
3-Methyl-4-OH-phenylglycol |
3-Methylhistidine |
4-Hydroxyphenylpyruvic Acid |
5-OH-Indoleacetic Acid |
8-OHdG |
APOE (Add-on) |
Adipic Acid |
Alanine |
Alpha-amino-N-butyric acid |
Alpha-aminoadipic acid |
Aluminum (Add-on) |
Anserine (dipeptide) |
Antimony (Add-on) |
Arachidic (Add-on) |
Arachidonic (Add-on) |
Arginine |
Arsenic (Add-on) |
Asparagine |
Aspartic acid |
Barium (Add-on) |
Behenic (Add-on) |
Benzoic |
Benzoic/Hippuric Acids Ratio |
Beta-alanine |
Beta-aminoisobutyric acid |
Bismuth (Add-on) |
COMT (V158M) (Add-on) |
Cadmium (Add-on) |
Calcium (Add-on) |
Carnosine (dipeptide) |
Cesium (Add-on) |
Chromium (Add-on) |
Cis-Aconitic Acid |
Citramalic Acid |
Citric Acid |
Citrulline |
Cobalt (Add-on) |
Copper (Add-on) |
Creatinine |
Creatinine (Add-on) |
Cystathionine |
Cysteine |
Cystine |
D-Arabinitol |
Dihomo-gamma-linolenic (Add-on) |
Dihydroxyphenylpropionic Acid |
Docosahexaenoic (Add-on) |
Docosapentaenoic (Add-on) |
Docosatetraenoic (Add-on) |
Eicosadienoic (Add-on) |
Eicosapentaenoic (Add-on) |
Elaidic (Add-on) |
Ethanolamine |
Formiminoglutamic Acid (FIGlu) |
Gadolinium (Add-on) |
Gallium (Add-on) |
Gamma-Linolenic (Add-on) |
Gamma-aminobutyric acid |
Glucose |
Glutamic acid |
Glutamine |
Glutaric Acid |
Glyceric Acid |
Glycine |
Glycolic Acid |
Hippuric |
Histidine |
Homovanillic Acid |
Indoleacetic Acid |
Iron (Add-on) |
Isocitric Acid |
Isoleucine |
Kynurenic Acid |
Lactic Acid |
Lead (Add-on) |
Leucine |
Lignoceric (Add-on) |
Linoleic (Add-on) |
Lipid Peroxides |
Lithium (Add-on) |
Lysine |
MTHFR (C677T and A1298C) (Add-on) |
Magnesium (Add-on) |
Malic Acid |
Manganese (Add-on) |
Margaric (Add-on) |
Mercury (Add-on) |
Methionine |
Methylmalonic Acid |
Molybdenum (Add-on) |
Nervonic (Add-on) |
Nickel (Add-on) |
Niobium (Add-on) |
Oleic (Add-on) |
Ornithine |
Orotic Acid |
Oxalic Acid |
Palmitic (Add-on) |
Palmitoleic (Add-on) |
Pentadecanoic (Add-on) |
Phenylacetic Acid |
Phenylalanine |
Phosphoethanolamine |
Phosphoserine |
Platinum (Add-on) |
Potassium (Add-on) |
Proline |
Pyroglutamic Acid |
Pyruvic Acid |
Rubidium (Add-on) |
Sarcosine |
Selenium (Add-on) |
Serine |
Stearic (Add-on) |
Strontium (Add-on) |
Suberic Acid |
Succinic Acid |
Sulfur (Add-on) |
TNF-a (Add-on) |
Taurine |
Thallium (Add-on) |
Thorium (Add-on) |
Threonine |
Tricosanoic (Add-on) |
Tryptophan |
Tungsten (Add-on) |
Uranium (Add-on) |
Urea |
Vaccenic (Add-on) |
Valine |
Vanadium (Add-on) |
Vanilmandelic Acid |
Zinc (Add-on) |
a-Hydroxybutyrate |
a-Keto-b-Methylvaleric Acid |
a-Ketoadipic Acid |
a-Ketoglutaric Acid |
a-Ketoisocaproic Acid |
a-Ketoisovaleric Acid |
alpha-Linolenic (Add-on) |
b-OH-Butyric Acid |
b-OH-b-Methylglutaric Acid |
CPT Codes | |
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1-Methylhistidine | 82139 |
2-Hydroxyphenylacetic Acid | 83921 |
3-Hydroxyproprionic Acid | 83921 |
4-Hydroxyphenylpyruvic Acid | 83921 |
5-OH-Indoleacetic Acid | 83497 |
8-OHdG | 83520 |
Adipic Acid | 83921 |
Aluminum (Add-on) | 82108 |
Antimony (Add-on) | 83015 |
Arachidic (Add-on) | 82542 |
Behenic (Add-on) | 82726 |
Cadmium (Add-on) | 82300 |
Calcium (Add-on) | 82340 |
Citric Acid | 82507 |
Creatinine | 82570 |
D-Arabinitol | 84311 |
Docosatetraenoic (Add-on) | 82726 |
Glutaric Acid | 83921 |
Glyceric Acid | 83945 |
Glycolic Acid | 83945 |
Homovanillic Acid | 83150 |
Isocitric Acid | 83921 |
Lactic Acid | 83605 |
Lead (Add-on) | 83655 |
Lignoceric (Add-on) | 82726 |
Lipid Peroxides | 84311 |
Magnesium (Add-on) | 83735 |
Malic Acid | 83921 |
Methylmalonic Acid | 83921 |
Nervonic (Add-on) | 82726 |
Nickel (Add-on) | 83885 |
Orotic Acid | 83921 |
Oxalic Acid | 83945 |
Pyruvic Acid | 84210 |
Suberic Acid | 83921 |
Succinic Acid | 83921 |
Tricosanoic (Add-on) | 82726 |
Vanilmandelic Acid | 84585 |
a-Hydroxybutyrate | 83921 |
a-Keto-b-Methylvaleric Acid | 83921 |
a-Ketoadipic Acid | 83921 |
a-Ketoglutaric Acid | 83921 |
a-Ketoisocaproic Acid | 83921 |
a-Ketoisovaleric Acid | 83921 |
Specimen Requirements |
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1 green-top preservative tube - FMV urine (frozen); 1 blue-top amber tube - FMV urine (frozen); 1 green-top tube - FMV urine (frozen); Additional add-ons include 1 bloodspot card; 2 genomic buccal swabs |