GI Effects® Microbial Ecology Profile

A Targeted Stool Test for Optimal Clinical Utility

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New GI Effects Reporting Enhancements

Genova Diagnostics is pleased to announce innovative reporting enhancements to the GI Effects Microbial Ecology stool profile.

New Features Include:

A Commensal Balance Infographic – Designed to provide a more precise view of an individual patient's commensal bacteria (PCR) results relative to a spectrum of healthy and unhealthy commensal patterns.

Commensal Bacteria Clinical Associations Chart – See how patient results compare to commensal bacteria (PCR) patterns seen in patients with specific clinical conditions:

  • IBS
  • IBD
  • Metabolic Syndrome
  • Chronic Fatigue
  • Autoimmune dysfunction
  • Type 2 Diabetes
  • High Blood Pressure
  • Mood Disorders

Correlations are now evident between many disease processes and patterns of microbiome dysbiosis in both gut dysfunction and extra-intestinal disorders.

Commensal Balance Infographic
Commensal Bacteria Clinical Associations Chart

Displayed in an expanded Interpretation At-a-Glance section, the new report enhancements provide informative data derived from Genova Diagnostics patient results archive. All results were obtained with the same Genova Diagnostics technology platform(s); this allows for an equivalent or 'like to like' comparison of an individual patient's results to various clinical conditions.

Proceed to Clinical Overview


Product Description

The GI Effects® Microbial Ecology Profile is a targeted stool test evaluating gut microbiome balance and assessing bacteria and parasites. Combining the best mix of molecular and culture technology, this stool test provides:

  • More Actionable Results using Top Technologies and Premier Biomarkers
    • PCR (Polymerase Chain Reaction), a molecular assay optimized for stool testing assesses 24 commensal bacteria associated in the scientific literature with health and disease, and provides valuable insight into the human microbiome.
    • O&P (ova & parasite), the gold standard for parasite identification
      • Choice of either 1 or 3 day collection, based on clinician index of suspicion for parasitic infection
      • If low/no suspicion, a one day sample will likely be adequate. If high suspicion, a 3-day sample collection is optimal
    • Enhanced Test Reporting that includes an Interpretation At-a-Glance overview that highlights clinically actionable biomarkers in two key areas of gut health: Infection and Imbalance
  • Broad Clinical Applications

    Gastrointestinal function is critical for good health. Emerging evidence in the scientific literature has associated gut microbiome status with a wide variety of common illnesses.

    Add-On Tests

    • Campylobacter
    • Clostridium difficile
    • Escherichia coli
    • Fecal Lactoferrin
    • Helicobacter pylori
    • Macro Exam for Worms
    • Stool Zonulin
    • KOH Preparation for Yeast

    Clinical Overview

    What is the GI Effects Microbial Ecology Profile?

    Primarily focusing on the “G” in the DIG format, our GI Effects Microbial Ecology Profile is a targeted stool test, offering the ability to detect and identify parasites, as well as providing valuable assessment of gut microbiota via 24 Commensal Bacteria targets.

    Gut Microbiome:

    • Commensal bacteria — the composition, diversity, and relative abundance of gut organisms, all of which are linked to both gastrointestinal and general health
      • More than 95% of commensal gut organisms are anaerobic and are difficult to recover by traditional (aerobic) culture techniques; molecular DNA techniques are now considered the standard for anaerobic bacteria assessment in research, permitting identification and quantification of multiple organisms with a single specimen.
      • The Polymerase Chain Reaction (PCR) methodology can identify bacterial populations at any level of taxonomy, as broadly as phylum and as narrowly as species. This ability permits analysis of the gut microbiome at a desired degree of complexity.
      • GI Effects assesses a key set of 24 clinically relevant genera/species that map to 7 major phyla
    • Bacterial and mycological culture — the presence of specific beneficial and pathological organisms
      • Traditional bacterial culture complements DNA-based tests to provide an expanded survey of a patient's gut microbiota, beyond the specific organisms targeted by PCR.
    • Parasitology
      • GI Effects provides microscopic examination of fecal specimens for ova and parasites (O&P), the gold standard of diagnosis for many parasites.
      • Enzyme immunoassay (EIA), widely recognized for its diagnostic utility in the detection of pathogenic antigens, is used for the identification of Cryptosporidium, Entamoeba histolytica, and Giardia lamblia.
    • Additional Biomarkers Available:
      • Campylobacter
      • Clostridium difficile
      • Escherichia coli
      • Fecal Lactoferrin
      • Helicobacter pylori
      • Macro Exam for Worms
      • Stool Zonulin
      • KOH Preparation for Yeast

    When Should the GI Effects Microbial Ecology Profile Be Considered?

    The GI Effects® Microbial Ecology Profile is a focused clinical tool in the management of patients with symptoms related to pathogenic organism and/or microbial imbalance. Such imbalances have been associated in the scientific literature with a wide variety of common illnesses.

    The GI Effects Microbial Ecology Profile is particularly helpful in monitoring changes to microbiota as targeted therapeutics are implemented.

    What Advantage does Microbial Ecology Profile Stool Testing Offer Compared to Other Diagnostics?

    GI Effects Microbial Ecology Profile represents the best technical platform available to assess the status of the gut ecosystem, combining an optimized PCR molecular assay for anaerobic bacteria, Matrix Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) technology for identification of cultivable species, and gold standard O&P (ova & parasites) for parasite detection.

    The test report is organized so that the clinician may move through results in a logical order that enhances clinical utility, starting with the Interpretation At-a-Glance pages that are comprised of the following:

    • Functional Pillars – Using evidence-based rules and weighted algorithms, this page synthesizes patient test results into Functional Pillars of clinical significance (Infection and Imbalance) and provides a directional indication of potential therapeutic next steps in patient management.
    • Commensal Balance – this infographic has been designed to provide a more precise view of an individual patients' commensal bacteria (PCR) results relative to a healthy cohort. It is composite of two measures:
      • The Healthy-Pattern Continuum (formerly known as the Diversity Association Index) is a progressive ranking scale based on a Genova proprietary algorithm that differentiates healthy and unhealthy commensal patterns. This algorithm is applied to an individual patient's GI Effects commensal bacteria (PCR) findings, and produces a numeric result ranging from 0 to 10 and is denoted by the 'y' axis of the Commensal Balance infographic.
      • The Reference Variance Score reflects the total number of an individual patient's commensal bacteria (PCR) results that are out of reference range. This number ranges from zero to 24, and is denoted by the 'x' axis of the Commensal Balance infographic.
    • Relative Abundance – this infographic represents the proportional levels of select phyla in an individual's microbiome and is represented relative to similar measures derived from a healthy cohort of individuals.
    • Commensal Clinical Associations Chart – to create this chart, Genova utilized the GI Effects test-results database which allowed comparison of commensal results in patients with self-reported clinical conditons (IBD, Metabolic Syndrome, Chronic Fatigue, Autoimmune dysfunction, Type 2 Diabetes, High Blood Pressure, Mood Disorders and ROME III criteria (IBS)) to those found in a healthy cohort. In addition, the chart feature patient results marked as high (H) or low (L) compared to the reference range for each commensal bacteria.

    What Can Clinicians and Patients Expect from GI Effects Microbial Ecology Profile Stool Testing?

    The results of the GI Effects Microbial Ecology Profile may effectively provide insight into the root cause(s) of gut symptoms originating from a disturbed gut ecosystem. Results can help to guide focused treatments designed to get patients back to good health. As identified functional imbalances in the gut microbiome become more normalized through targeted dietary, lifestyle, and supplementation therapeutics, intractable symptoms often improve for many patients.

    Each biomarker is associated with specific pertinent therapies, but general therapeutic considerations include:

    • Discerning general evidence of bowel inflammation and providing intestinal mucosal and anti-inflammatory support
    • Addressing any identified infection with appropriate pharmacological and botanical treatments
    • Supporting commensal bacteria with pre/probiotic supplements and dietary changes

    A targeted diagnostic panel, like the GI Effects Microbial Ecology Profile, is particularly helpful in monitoring changes to microbiota as individualized therapeutics are implemented. It also provides enhanced clinical accuracy in determining which patients may need more comprehensive stool testing.

    Test Type: Stool Test

Analyte List
Akkermansia muciniphila
Anaerotruncus colihominis
Bacteriology
Bacteroides vulgatus
Bacteroides-Prevotella group
Barnesiella spp.
Bifidobacterium longum
Bifidobacterium spp.
Butyrivibrio crossotus
Clostridium spp.
Collinsella aerofaciens
Color
Consistency
Coprococcus eutactus
Desulfovibrio piger
Escherichia coli
Faecalibacterium prausnitzii
Fecal Occult Blood
Firmicutes/Bacteroidetes (F/B Ratio)
Fusobacterium spp.
Lactobacillus spp.
Methanobrevibacter smithii
Mic Sensitivities, Yeast or Bacteria
Microscopic Exam Results
Mycology (Yeast/Fungi)
Odoribacter spp.
Other Biomarkers
Oxalobacter formigenes
Parasitology
Parasitology EIA Tests
Prevotella spp.
Pseudoflavonifractor spp.
Roseburia spp.
Ruminococcus spp.
Veillonella spp.
CPT Codes  
Specimen Requirements