A Comprehensive Tool to Assess the HPA Axis — Stress Response and Resiliency
The Adrenal Stress Profile (ASP) provides an assessment of the Hypothalamic-Pituitary-Adrenal (HPA) axis using carefully timed salivary samples of the hormones cortisol and DHEA. Salivary testing is an easy, non-invasive option to measure unbound, biologically active parent hormone levels. The report offers an easy-to-interpret graphic which plots the results of cortisol's natural diurnal rhythm.
DHEA is measured once in the 7:00 – 9:00 AM sample and a ratio of DHEA to cortisol is calculated to provide insight into anabolic/catabolic balance.
Daily hassles, chronic pain, blood sugar dysregulation, work stressors, and poor relationship quality can alter the HPA axis. Imbalances in adrenal hormones can have a wide range of negative consequences that can adversely impact a patient's overall quality of life. The symptoms of HPA axis dysfunction can be vague, and are highly variable, but may include: fatigue, insomnia, weight gain, depression, GI complaints, and chronic pain. HPA axis dysfunction is associated with many conditions including:
- cardiovascular disease
- gastrointestinal and immune dysregulation
- diabetes and metabolic syndrome
- chronic fatigue
- persistent pain
- neurodegenerative disease and cognitive decline
Adrenal Stress Profile testing can reveal these HPA axis imbalances and provide direction for clinical intervention with targeted therapeutic treatments, such as nutrient support and/or adaptogens, stress management, behavioral modification, and lifestyle interventions.
Cortisol Awakening Response (CAR)
- Two awakening samples to evaluate CAR
- CAR is a transient, immediate rise in cortisol upon awakening and is distinct from the diurnal rhythm. CAR reflects a person's ability to cope with anticipated challenges and their perception of control around chronic stress, providing insight into HPA axis resiliency.
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4 saliva samples (5ml) collected at specific times over a 24-hour period (frozen)