IgE Food Antibodies

Identify True Food Allergies

The IgE Food Antibody Assessment is a blood test that measures IgE antibodies to 19 of the most allergenic foods. The panel also includes a total IgE measurement. The body can react to foods in many different ways. The prevalence of food allergies in Western countries is rising, with up to 10% of the population affected. This trend likely involves a complex interplay between genetic, epigenetic, and environmental risk factors.1

When should testing for IgE Food Antibodies be considered?

Testing for IgE food antibodies is useful for individuals who suspect that a food is responsible for causing their symptoms. The presence of circulating antibodies may affect each patient differently. According to the American Academy of Allergy, Asthma, and Immunology, "A key message is that a positive allergy test result (skin or blood) indicates only the presence of allergen-specific IgE (called sensitisation). It does not necessarily mean clinical allergy (i.e., allergic symptoms with exposure)."2 Therefore, test results should always be viewed in the context of the overall clinical picture.

Conditions associated with IgE food allergy

  • Hives or red, itchy skin
  • Stuffy or itchy nose, sneezing or itchy, teary eyes
  • Vomiting, stomach cramps or diarrhea
  • Angioedema or swelling
  • Shortness of breath or wheezing
  • Anaphylaxis

Risk factors associated with IgE food allergies

Certain allergy risk factors cannot be modified including male sex in children, race/ethnicity (increased among Asian and black children compared with white children), and genetics (familial associations, HLA, and specific genes). However, the following risk factors can be addressed to reduce/prevent food allergy:1

  • Increased hygiene
  • Microbiome imbalance
  • Atopic disease manifestations (comorbid atopic dermatitis)
  • Vitamin D insufficiency
  • Dietary fat (reduced consumption of omega-3-polyunsaturated fatty acids)
  • Reduced consumption of antioxidants
  • Increased antacid use (reducing digestion of allergens)
  • Obesity (being in an inflammatory state)
  • Timing and route of exposure to foods

Ordering the test

The IgG Food Antibody Panel can be ordered as a stand-alone test or bundled with other profiles. Often times, clinicians will bundle several smaller profiles in order to see a more complete picture of the patient's immune-mediated response. Profiles that can be bundled include:

Profile Includes
IgG Foods 87 foods plus total IgE
IgG Vegetarian 21 foods plus total IgE
IgG Spices 24 spices plus total IgE
IgE Foods 19 foods plus total IgE
IgE Moulds 15 molds plus total IgE
IgE Inhalants 25 inhalants specific to the UK region plaus total IgE
Coeliac and Gluten Sensitivity Total IgA, tTG IgA, DGP IgA, EMA IgA, Anti-Gliadin IgG & IgA

What advantage does the IgE Food Antibody test offer compared to other diagnostics?

An IgE allergic response involves immediate-hypersensitivity to a substance. It is generally easier for patients and clinicians to identify a food that causes an immediate response, although not always, and testing serum IgE antibodies can be helpful.

The National Institute of Allergy and Infectious Disease (NIAID) guidelines state that a combination of medical history, physical examination, and oral food challenge can assist in the diagnosis of food allergy, with the oral food challenge being the gold standard.3 In some instances, an oral food challenge may be dangerous for the patient and other tools may be helpful.

A skin-prick test involves the injection of an allergen on the skin then observation for a reaction. This method has low specificity and low positive predictive value,3 and the injection of a substance that can potentially cause a serious reaction should be monitored closely. Serum testing can be especially useful when skin-prick tests cannot be performed (for example, due to extensive dermatitis or dermatographism), or when antihistamines cannot be discontinued.

Allergen-specific serum IgE testing does not involve introducing an allergen in order to test. Instead, already circulating antibodies are measured, however, the patient must have been exposed to the allergen in the days leading up to testing in order to detect antibodies. The NIAID suggests, "sIgE tests are useful for identifying foods potentially provoking IgE-mediated food-induced allergic reactions and specified "cutoff" levels, defined as 95% predictive values, may be more predictive than skin prick tests of clinical reactivity in certain populations, but when used alone they are not diagnostic of food allergy."3

Genova's Methodology

IgE Antibody Testing

Genova utilises the FDA-cleared Siemans Immulite® 2000 Total IgE and 3gAllergy Specific IgE Universal Kits. Immulite® 2000 Total IgE is a solid-phase Chemiluminescent assay. Immulite® 3gAllergy Specific IgE is a solid phase, two-step, chemiluminescent immunoassay that exploits liquid phase kinetics in a bead format. Siemens proprietary liquid allergens are the key to making IMMULITE® 2000 Immunoassay allergy tests sensitive, specific, and reliable. The soluble polymer/copolymer support for the allergens increases the number of binding sites and their accessibility to allergen-specific IgE antibodies. Enzyme-enhanced chemiluminescent signal detection provides increased sensitivity and the proprietary wash technique enhances specificity.

What can clinicians and patients expect from IgE Food Antibody testing?

In general, clinical management of the patient with food allergies involves the elimination of offending food(s). Modifiable risk factors (see above) may simultaneously be addressed with diet, botanicals, nutraceuticals, and lifestyle changes.

Please visit our IgG, IgE, and Coeliac Tests Prep page prior to ordering the test to learn about medications that may impact test results, length of exposure to antigens, pediatric testing, and diseases that may affect antibody levels.

References

  1. Sicherer S and Sampson H. Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management. J All Clin Immunol. 2018;141(1):41-58.
  2. Cox L, Williams B, Sicherer S, et al. Pearls and pitfalls of allergy diagnostic testing: Report from the American college of allergy, asthma and immunology/American academy of allergy, asthma and immunology specific IgE test task force. Annals of allergy, asthma & immunology: official publication of the American College of Allergy, Asthma, & Immunology. 2009;101(6):580–92.
  3. NIAID- Sponsored Expert Panel. Guidelines for the Diagnosis and Management of Food Allergy in the United States: Report of the NIAID-Sponsored Expert Panel. J All Clin Immunol. 2010;126(6 suppl):S1-58.

NOTES:
When ordering the IgG Food Antibodies test, it will be listed as “Allergy Antibody” on the Order Menu.
* IgG Food Antibody Assessment is not available in New York.

Test Type: Blood Test

Analyte List
Almond - IgE
Blue Mussel - IgE
Brazil Nut - IgE
Buckwheat - IgE
Coconut - IgE
Cod - IgE
Corn - IgE
Cow's Milk - IgE
Egg White - IgE
Hazelnut - IgE
Oat - IgE
Peanut - IgE
Rice - IgE
Salmon - IgE
Sesame - IgE
Shrimp - IgE
Soy - IgE
Total IgE
Tuna - IgE
Wheat - IgE
Specimen Requirements
3ml serum in transfer tube (frozen)