Metabolic Analysis Profile (Organic Acids)

Metabolic Analysis Profile (Organic Acids)

The Metabolic Analysis Profile is a nutritional test that assesses urine metabolites in order to evaluate four critical areas of metabolism: gastrointestinal function, cellular and mitochondrial energy production, neurotransmitter processing, and amino acid/organic acid balance as influenced by vitamin/mineral cofactors. Results can be used to address chronic systemic complaints ranging from chronic fatigue and mood disorders to headache, muscular/joint pain, and digestive problems.

The Metabolic Analysis Profile is a nutritional test using an urinary assessment of 46 key organic acids grouped according to their primary roles in the following four central areas of metabolism.
Gastrointestinal Function — This profile measures eight markers that can reveal malabsorption and dysbiosis. These imbalances can be addressed to improve gut health and to help prevent or alleviate: chronic digestive problems, common causes of nutritional deficiency, yeast overgrowth, cognitive impairment, gastrointestinal distress, and degenerative conditions.

Energy Production —This profile assesses metabolites that serve as important intermediates in the citric acid (Krebs) cycle. This cycle supplies the body with its primary energy needs, converting 90% of food energy into cellular energy. This subpanel also includes:

  • Carbohydrate metabolites that can signal impaired glucose metabolism
  • Markers that help evaluate the breakdown of fats and production of cholesterol
  • A marker measuring the production of coenzyme Q10

Imbalances of cellular energy metabolites are linked with chronic fatigue, accelerated cell breakdown, and unhealthy aging.

Neurotransmitter Metabolites - A special grouping of neurotransmitter metabolites serve as important diagnostic indicators of abnormal metabolism that can underline many key aspects of neuropsychiatric function. These markers are urinary metabolites of powerful neurotranmitters that act on the central nervous system, including: Epinephrine, Dopamine, and Serotonin. These substances can profoundly influence patterns of stress response, emotional well-being, cognition, and sleep.

Assessment of Nutrient Sufficiency — This nutritional test provides a functional assessment of nutrient sufficiency and usage that covers a broad range of vitamins, coenzymes, elements, enzyme activators, and other nutrients.  An analysis of amino acid metabolites which require vitamin and mineral cofactors for their metabolism can hint at deficiencies of: vitamins B6, B12 and C, magnesium, copper, iron, and various amino acids.

The reference ranges for this test apply to children (2 — 12 years) and adults.

Test Type: Urine Test


  • 2-Hydroxyphenylacetic Acid
  • 3-Hydroxyproprionic Acid
  • 3-Methyl-4-OH-phenylglycol
  • 4-Hydroxyphenylpyruvic Acid
  • 5-OH-Indoleacetic Acid
  • Adipic Acid
  • Arabinose
  • Benzoic
  • Benzoic/Hippuric Acids Ratio
  • Cis-Aconitic Acid
  • Citramalic Acid
  • Citric Acid
  • Creatinine
  • Dihydroxyphenylpropionic Acid
  • Formiminoglutamic Acid (FIGlu)
  • Fumaric Acid
  • Glutaric Acid
  • Hippuric
  • Homogentisic Acid
  • Homovanillic Acid
  • Indoleacetic Acid
  • Isocitric Acid
  • Kynurenic Acid
  • Lactic Acid
  • Malic Acid
  • Methylmalonic Acid
  • Orotic Acid
  • Phenylacetic Acid
  • Pyroglutamic Acid
  • Pyruvic Acid
  • Suberic Acid
  • Succinic Acid
  • Tartaric Acid
  • Vanilmandelic Acid
  • a-Keto-b-Methylvaleric Acid
  • a-Ketoadipic Acid
  • a-Ketoglutaric Acid
  • a-Ketoisocaproic Acid
  • a-Ketoisovaleric Acid
  • b-OH-Butyric Acid
  • b-OH-b-Methylglutaric Acid


  •  2-Hydroxyphenylacetic Acid83921  
  •  3-Hydroxyproprionic Acid83921  
  •  4-Hydroxyphenylpyruvic Acid83921  
  •  5-OH-Indoleacetic Acid83497  
  •  Adipic Acid83921  
  •  Citric Acid82507  
  •  Creatinine82570  
  •  Glutaric Acid83921  
  •  Homogentisic Acid83921  
  •  Homovanillic Acid83150  
  •  Isocitric Acid83921  
  •  Lactic Acid83605  
  •  Malic Acid83921  
  •  Methylmalonic Acid83921  
  •  Orotic Acid83921  
  •  Pyruvic Acid84210  
  •  Suberic Acid83921  
  •  Succinic Acid83921  
  •  Vanilmandelic Acid84585  
  •  a-Keto-b-Methylvaleric Acid83921  
  •  a-Ketoadipic Acid83921  
  •  a-Ketoglutaric Acid83921  
  •  a-Ketoisocaproic Acid83921  
  •  a-Ketoisovaleric Acid83921  
  •  b-OH-Butyric Acid83921  
  •  b-OH-b-Methylglutaric Acid83921  

Specimen Requirements:  First morning urine collection; one tube of 10ml - needs to be full (samples frozen)

Turn Around Time: 

14 Days

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