Collection Pack
Collection Pack
Specialty Testing

Specimen Type: Buccal Swab

Not available in New York state.

Only healthcare providers licensed in their state may order laboratory testing. 

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Why choose Genova Diagnostics' Genomic Products?

Specialized genomic testing can provide a glimpse into a patient’s potential health future and help you influence the ultimate outcome. 

A simple cheek swab can be conveniently collected at home.

Educational report commentary is specific to the SNP finding, including health implications and clinical management considerations.

DetoxiGenomic® Profile and a la carte SNPs to assess risk

According to the CDC, precision medicine, also called personalized medicine, is an individualized approach to patient care taking into account genetics, lifestyle, and environmental factors. Single Nucleotide Polymorphisms, or SNPs, are genetic variants that may predispose your patients to numerous chronic diseases. Testing can help clinicians identify a patient’s genetic predispositions and tailor therapeutics accordingly.

 

Who can benefit from SNP testing?

Researchers have identified thousands of SNPs that relate to almost every chronic disease. Truth is, everybody has SNPs. SNPs are common and generally do not result in life-threatening presentations like genetic mutations, which are rare. SNPs are more subtle and act by reducing cellular functions and ultimately an optimal quality of life. Genomic testing can minimize risk by identifying hidden gene polymorphisms that may promote chronic disease. Many people mistakenly assume that the presence of a SNP means they are destined to experience the associated disease. Fortunately, most genes have flexible expressions and often are influenced by modifiable environmental, diet, and lifestyle factors.

In some instances, genotypic SNP testing may prompt phenotypic monitoring of associated biomarkers. For example, if a patient has a polymorphism for MTHFR, homocysteine may be more closely monitored.

SNP testing may be appropriate for patients with:

  • Chronic conditions that resist treatment
  • Family history of cardiovascular disease, mood disorders, Alzheimer’s, cancer, or autoimmune disease
  • Inflammatory conditions
  • Cardiovascular disease
  • Mood disorders
  • Osteoporosis
  • Metabolic disorders (insulin resistance)
  • Chemical sensitivity
  • Asthma and lung problems
  • Cognitive decline

 

About the Genomic Offerings
  • DetoxiGenomic Profile evaluates over 20 SNPs related to phase 1 and phase 2 detoxification pathways. These SNPS are associated with increased risk of impaired detoxification capacity especially when exposed to environmental toxins. It also identifies individuals potentially susceptible to adverse drug reactions. See sample report for list of SNPs.
  • A la carte SNPs
    • ApoE – Apolipoprotein E is involved in lipid metabolism and certain polymorphisms can result in increased cardiovascular disease risk and Alzheimer’s disease.1,2
    • COMT – Catechol-O-Methyltransferase polymorphisms can result in reduced enzyme activity associated with neuropsychiatric disorders, impaired estrogen metabolism, and increased sensitivity to pain.3,4
    • GSTP1 or GSTM1 – Glutathione S-Transferase polymorphisms are associated with a decreased ability to detoxify a majority of substances, which can result in oxidative stress and chronic disease risk.5
    • MTHFR (C677T, A1298C) – Methyl tetrahydrofolate Reductase - Polymorphisms of this enzyme can disrupt the metabolism of homocysteine, resulting in its accumulation as well as impaired methylation. The presence of these SNPs can increase risk of cardiovascular disease, blood vessel damage, thrombosis (blood clots), stroke, and degenerative aging.6
    • SOD2 – Superoxide Dismutase is an antioxidant enzyme and polymorphisms are associated with reduced SOD activity, increasing risk of oxidative stress.7,8
    • TNFα – Tumor Necrosis Factor-alpha is a proinflammatory cytokine and polymorphisms are associated with inflammation, oxidative stress, and numerous disease implications.9
    • VDR – Vitamin D Receptor polymorphisms are associated with decreased bone density and osteoporosis.10
  • SNPs available as add-ons to other profiles including
    • NutrEval and Metabolomix+ – MTHFR, COMT, ApoE, TNF-α
    • Methylation Panel – MTHFR, COMT, CBS, MTRR, MAT1A, SHMT1, MTR, BHMT, GNMT
    • Essential Estrogens – CYP1B1, MTHFR, COMT, VDR

 

Do you want to take an active role in your health destiny? Genomic testing can provide insights.

If you have a family history of disease and you are wondering about your own predisposition, you may consider genomic testing. The good news is that your genes are not your destiny. The genetic markers measured on Genova’s profiles assess genes that can be beneficially influenced by making diet and lifestyle changes. You can make healthy changes that may impact genetic expression and disease prevention.

Genova’s genomics profiles are ideal for patients who want to understand more about their genetic predisposition to the following conditions:

  • Family history of heart disease, mood disorders, Alzheimer’s, cancer, or autoimmune disease
  • Inflammatory conditions
  • Heart disease
  • Mood disorders (depression, anxiety)
  • Osteoporosis
  • Metabolic disorders (insulin resistance)
  • Chemical sensitivity
  • Asthma and lung problems
  • Memory issues or brain fog

 

What to Expect

Genova’s genomics testing requires a simple cheek swab to assess important genetic variations. We have many resources to help make your testing experience a success. Review the Test Preparation tab to learn more about the collection process.

Preparing for this Test

Night Before Collection

The night before collection, use your normal nightly routine of brushing and flossing of teeth, but do not use mouthwash.

Morning of Collection

Specimen must be collected immediately upon rising. On the morning of collection, do not eat, brush or floss your teeth, use mouthwash, chew gum or use any tobacco, or coffee products. You may drink ONLY water before specimen collection. Just prior to collection, wash your hands completely with hand soap.

Support Materials

 
Collection Video

Collection Instructions
Sample Report

 

DetoxiGenomic® Profile and a la carte SNPs to assess risk

According to the CDC, precision medicine, also called personalized medicine, is an individualized approach to patient care taking into account genetics, lifestyle, and environmental factors. Single Nucleotide Polymorphisms, or SNPs, are genetic variants that may predispose your patients to numerous chronic diseases. Testing can help clinicians identify a patient’s genetic predispositions and tailor therapeutics accordingly.

 

Who can benefit from SNP testing?

Researchers have identified thousands of SNPs that relate to almost every chronic disease. Truth is, everybody has SNPs. SNPs are common and generally do not result in life-threatening presentations like genetic mutations, which are rare. SNPs are more subtle and act by reducing cellular functions and ultimately an optimal quality of life. Genomic testing can minimize risk by identifying hidden gene polymorphisms that may promote chronic disease. Many people mistakenly assume that the presence of a SNP means they are destined to experience the associated disease. Fortunately, most genes have flexible expressions and often are influenced by modifiable environmental, diet, and lifestyle factors.

In some instances, genotypic SNP testing may prompt phenotypic monitoring of associated biomarkers. For example, if a patient has a polymorphism for MTHFR, homocysteine may be more closely monitored.

SNP testing may be appropriate for patients with:

  • Chronic conditions that resist treatment
  • Family history of cardiovascular disease, mood disorders, Alzheimer’s, cancer, or autoimmune disease
  • Inflammatory conditions
  • Cardiovascular disease
  • Mood disorders
  • Osteoporosis
  • Metabolic disorders (insulin resistance)
  • Chemical sensitivity
  • Asthma and lung problems
  • Cognitive decline

 

About the Genomic Offerings
  • DetoxiGenomic Profile evaluates over 20 SNPs related to phase 1 and phase 2 detoxification pathways. These SNPS are associated with increased risk of impaired detoxification capacity especially when exposed to environmental toxins. It also identifies individuals potentially susceptible to adverse drug reactions. See sample report for list of SNPs.
  • A la carte SNPs
    • ApoE – Apolipoprotein E is involved in lipid metabolism and certain polymorphisms can result in increased cardiovascular disease risk and Alzheimer’s disease.1,2
    • COMT – Catechol-O-Methyltransferase polymorphisms can result in reduced enzyme activity associated with neuropsychiatric disorders, impaired estrogen metabolism, and increased sensitivity to pain.3,4
    • GSTP1 or GSTM1 – Glutathione S-Transferase polymorphisms are associated with a decreased ability to detoxify a majority of substances, which can result in oxidative stress and chronic disease risk.5
    • MTHFR (C677T, A1298C) – Methyl tetrahydrofolate Reductase - Polymorphisms of this enzyme can disrupt the metabolism of homocysteine, resulting in its accumulation as well as impaired methylation. The presence of these SNPs can increase risk of cardiovascular disease, blood vessel damage, thrombosis (blood clots), stroke, and degenerative aging.6
    • SOD2 – Superoxide Dismutase is an antioxidant enzyme and polymorphisms are associated with reduced SOD activity, increasing risk of oxidative stress.7,8
    • TNFα – Tumor Necrosis Factor-alpha is a proinflammatory cytokine and polymorphisms are associated with inflammation, oxidative stress, and numerous disease implications.9
    • VDR – Vitamin D Receptor polymorphisms are associated with decreased bone density and osteoporosis.10
  • SNPs available as add-ons to other profiles including
    • NutrEval and Metabolomix+ – MTHFR, COMT, ApoE, TNF-α
    • Methylation Panel – MTHFR, COMT, CBS, MTRR, MAT1A, SHMT1, MTR, BHMT, GNMT
    • Essential Estrogens – CYP1B1, MTHFR, COMT, VDR

 

Do you want to take an active role in your health destiny? Genomic testing can provide insights.

If you have a family history of disease and you are wondering about your own predisposition, you may consider genomic testing. The good news is that your genes are not your destiny. The genetic markers measured on Genova’s profiles assess genes that can be beneficially influenced by making diet and lifestyle changes. You can make healthy changes that may impact genetic expression and disease prevention.

Genova’s genomics profiles are ideal for patients who want to understand more about their genetic predisposition to the following conditions:

  • Family history of heart disease, mood disorders, Alzheimer’s, cancer, or autoimmune disease
  • Inflammatory conditions
  • Heart disease
  • Mood disorders (depression, anxiety)
  • Osteoporosis
  • Metabolic disorders (insulin resistance)
  • Chemical sensitivity
  • Asthma and lung problems
  • Memory issues or brain fog

 

What to Expect

Genova’s genomics testing requires a simple cheek swab to assess important genetic variations. We have many resources to help make your testing experience a success. Review the Test Preparation tab to learn more about the collection process.

Preparing for this Test

Night Before Collection

The night before collection, use your normal nightly routine of brushing and flossing of teeth, but do not use mouthwash.

Morning of Collection

Specimen must be collected immediately upon rising. On the morning of collection, do not eat, brush or floss your teeth, use mouthwash, chew gum or use any tobacco, or coffee products. You may drink ONLY water before specimen collection. Just prior to collection, wash your hands completely with hand soap.

Support Materials

 
Collection Video

Collection Instructions
Sample Report

 

How it Works

Consult Doctor

Your doctor will discuss your symptoms and help decide which test is right for you.

Many specimen collections can be completed from the privacy of your home.

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Activate Test

Collection packs can be dropshipped directly to your home and everything you need to begin testing is included.

Already have a collection pack? Activate your test and begin today.

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Collect Samples

Use a calendar to plan for your collection.

Follow instructions carefully and be sure to add important details about you and your specimens in the Activation portal.

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Ship to Lab

Ship your specimens using the prepaid FedEx materials provided.

Results are available online. Schedule time with your physician to review results and create a plan for your health.

FAQ

Review information on the Test Preparation tab above for details on how medications and supplements may impact this test.

We provide a variety of testing services, and some of them may or may not be covered by your insurance plan.

Once your physician has ordered a Genova Diagnostics test for you, you can submit the CPT codes for your test to your commercial insurance plan to determine coverage. For information about billing options, please visit the Billing Information page.

Support guides, charts, and additional aids can be found on the Support Materials tab. Additional educational materials can be found in our Learning Library.

Genova also offers complimentary Medical Education Consultations for healthcare providers. Schedule consults online by signing in to your myGDX account.