Clinical Pearls
Tired of Being Tired?

An Update on Adrenal Dysfunction and CAR


Filomena Trindade MDCortisol is the body's main stress hormone. Under ideal circumstances, it is released in a natural diurnal circadian pattern. However, as we face many different daily stressors, additional cortisol release is provoked. Repeated activation of this "fight or flight" response can lead to HPA axis disruption and dysregulation.

In addition to cortisol's circadian rhythm, there is a separate and distinct transient increase in cortisol triggered by the act of waking in the morning. This is called the "Cortisol Awakening Response" or CAR. This response offers additional insight into the resiliency of the HPA axis and has distinct health implications.

Assessing cortisol using both CAR and the diurnal rhythm helps to identify abnormalities and allows clinicians to address root causes. In this webinar, Dr. Filomena Trindade discusses the causes of adrenal dysfunction, the interpretation of cortisol and CAR results, and the approach to treatment.


Clinical Pearls

Common Causes
Common Causes

Clinical Pearl 1

A wide variety of stressors, exposures, and other conditions can lead to adrenal dysfunction and changes to the CAR. Listen as Dr. Filomena Trindade discusses the common causes.

Play – Common Causes

Common Causes
Treatment Approach

Clinical Pearl 2

The treatment of adrenal dysfunction may require multiple interventions and should be adjusted for the stage of dysfunction. Here Dr. Filomena Trindade explains her multi-tiered approach to treatment.

Play – Treatment Approach

Tired of Being Tired? An Update on Adrenal Dysfunction and CAR

Daily hassles, chronic pain, blood sugar dysregulation, work stressors, and poor relationship quality can alter the HPA axis. Imbalances in adrenal hormones can have a wide range of negative consequences that can adversely impact a patient's overall quality of life.

The symptoms of HPA axis dysfunction can be vague and are highly variable but may include: fatigue, insomnia, weight gain, depression, GI complaints, and chronic pain. CAR and Adrenocortex Stress Profile testing can reveal these HPA axis imbalances and provide direction for clinical intervention with targeted therapeutic treatments such as nutrient support and/or adaptogens, stress management, behavioral modification, and lifestyle interventions.

Join Dr. Filomena Trindade as she reviews the causes, interpretation, and treatment of HPA axis dysfunction in the webinar entitled "Tired of Being Tired? An Update on Adrenal Dysfunction and CAR."

This webinar can be viewed in its entirety on our LIVEGDX webinar archive.

LIVEGDX Webinar Archive