CV Health™

The CV Health™ profile is a nutritional test that analyzes blood for lipid markers and independent risk factors leading to cardiovascular disease (CVD). These nutritional markers provide a thorough assessment of cardiovascular health status, revealing the biochemical environment associated with inflammation, lipid deposits, endothelial dysfunction, and clotting factors underlying cardiovascular disease. Using NMR fractionation technology for state-of-the-art lipid markers and independent risk factors, this nutritional test illuminates the complexity of cardiovascular disease (CVD).

The CV Health Profile is a comprehensive nutritional test featuring an advanced lipid profile that utilizes NMR fractionation technology, independent risk markers (including lipoprotein-associated phospholipase or Lp-PLA2), and a novel Insulin Resistance Score. All of these advanced markers play a critical role in the cardiovascular health. The insight they provide allows clinicians to more accurately address abnormalities relating to cardiac and vascular diseases.

Nearly 50% of all heart attack victims have normal levels of typical markers for CVD, including total cholesterol. For this reason, improved clinical tools are needed to identify patients with a predisposition to CVD who can benefit from timely, preventative intervention. With its unique combination of standard lipid markers, lipid fractionation analysis, and novel independent risk factors, the CV Health Profile assists physicians in identifying nearly 85% of individuals at risk for cardiovascular disease.

Nutritional Testing and Advanced Markers for Cardiovascular Disease

  • LDL-Particle Number (LDL-P) includes small and large LDL particles, and is independent of the cholesterol concentration within the particles. And individual with low/normal LDL-C concentration, but high LDL-P, is still at high-risk for plaque build-up. Increased LDL-P is associated with increased risk of carotid atherosclerosis, angina, myocardial infarction, and future coronary events.
  • HDL-Particle Number (HDL-P) indicates increased risk of coronary events for individuals with a low HDL-P number, and is independent of major lipid and non-lipid CVD risk factors. HDL-P is an important secondary risk factor, as it strongly relates to atherosclerosis in those individuals with optimal levels of LDL-P. Increasing HDL-C without increasing HDL-P offers little clinical benefit.
  • LDL-Size is highly associated with triglycerides and insulin resistance. Individuals with a preponderance of LDL particles of smaller size are at increased risk for coronary artery disease (CAD) and increased CAD severity.
  • Lipoprotein(a) or LP(a) is influenced by heredity and has a strong association with coronary and peripheral cardiac events.
  • hs C-reactive protein (hs-CRP) is an independent marker for systemic inflammation. High levels are linked to coagulation and vascular endothelium damage.
  • Lipoprotein-associated phospholipase (Lp-PLA2), aka PLAC, is produced in the intima, promoting inflammation and plaque instability. It is specific for vascular inflammation.
  • Homocysteine is an amino acid that has been linked to damaged endothelium, increased platelet aggregation, and the formation of atherosclerotic lesions.
  • Fibrinogen plays a key role in arterial occlusion by promoting thrombus formation, endothelial injury, and hyper-viscosity.
  • Insulin Resistance Score is determined by lipid sub-fractionation.

Test Type: Saliva Test, Blood Test

Analyte List
Fibrinogen
HDL
HDL-P
Homocysteine
LDL
LDL-P
LDL-Size
Lp(a)
Lp-PLA2
Total Cholesterol
Triglycerides
VLDL-L
VLDL-Size
hs C-Reactive Protein
Specimen Requirements
1 x 4ml serum, 3ml plasma, and 5ml Z-serum separator, fasting