(A biomarker that evaluates exocrine pancreatic function)
Video: IBS and Exocrine Pancreatic Insufficiency - [0:41]
This brief overview describes the significance of measuring Pancreatic Elastase.
PE-1 is a proteolytic enzyme exclusively secreted by the pancreas. Analyzing fecal PE-1 is a useful, non-invasive way of evaluating pancreatic exocrine function and identifying exocrine pancreatic insufficiency (EPI). Low values of PE-1 indicate EPI, which is associated with a variety of gastrointestinal symptoms and illnesses.
Patients for whom PE1 testing may be useful include those with:
In addition, EPI may occur secondary to:
Results that indicate pancreatic exocrine insufficiency warrant further investigation to determine the “root cause” of the dysfunction. Pancreatic enzyme replacement therapy (PERT), based on the level of insufficiency identified, is used to support patients with EPI. In reporting results, levels of exocrine pancreatic function are classified as follows:
PE-1 is a biomarker component of our GI Effects® Stool Profile, which utilizes the best technologies available to manage gut health. However, PE-1 can also be ordered as a single biomarker assay. If you are a clinician and would like more information about PE-1, please contact our Client Services team at 800-522-4762.