Targeting the Root
Causes of Stress

Presented by Thomas G. Guilliams, Ph.D.

While most of us think of the HPA axis as a "stress" responding system (which it is), we often forget to place the HPA axis into its larger context, that of metabolic regulator. In fact, when we look at the classic HPA axis signaling molecules (i.e., CRH, ACTH, and Cortisol) we find that they regulate a wide range of metabolic functions in both stress and unstressed environments.

This webinar will help orient the clinician to a number of other pathways by which the HPA axis functions to modulate and coordinate normal (and stress-induced) metabolism. We will especially focus on the circadian metabolism and show the important connection between the light/dark entrainment of the central clock and the nutrient signals that function at the peripheral clocks. The importance of finding a robust circadian cortisol rhythm (rather than merely the relative levels of cortisol) will be emphasized. Finally, understanding that responding to a metabolic crisis and anticipating a metabolic crisis can elicit the same HPA axis response, help underline the importance of addressing psychosocial stressors in at-risk subjects.


  • Reframe the Stress Response within the larger metabolic function of the HPA axis
  • Describe additional components of the HPA axis as key metabolic signals
  • Discuss the function of circadian metabolism as a primary regulator of the HPA axis
  • Define the Responsive and Anticipatory signals that Trigger the HPA axis

Thomas G. Guilliams, Ph.D.Michael Chapman, ND

Thomas G. Guilliams, Ph.D. (Tom) earned his doctorate in molecular immunology from the Medical College of Wisconsin in Milwaukee. For the past two decades, he has spent his time investigating the mechanisms and actions of lifestyle and nutrient-based therapies, and is an expert in the therapeutic uses of dietary supplements. Tom serves as an adjunct assistant professor at the University of Wisconsin- School of Pharmacy and is the VP of Science for Ortho Molecular Products. Since 2014 he has been writing a series of teaching manuals (Road maps) that outline and evaluate the evidence for the principles and protocols that are fundamental to the functional and integrative medical community.

He is the founder and director of the Point Institute, an independent research and publishing organization that facilitates the distribution of his many publications. A frequent guest-speaker, Dr. Guilliams provides training to a variety of health care disciplines in the use of lifestyle and natural medicines. He lives in the woods outside of Stevens Point, Wisconsin with his wife and children.