Lifestyle Medicine and the Methylome

Presented by Kara Fitzgerald, ND

DNA methylation plays a central, potentially lasting, (and heritable) regulatory role in health and disease. Aberrant methylation patterns, resulting in regions of hyper- and hypomethylation, influence the course of most, if not all, chronic disease. In cancer, it is understood that epimutations outpace genetic mutations 10:1. It's also understood that lifestyle factors can profoundly influence epigenetic methylation expression. Integrative and Functional Medicine clinicians, in employing a systems approach to care, are arguably best suited to optimize their patient's genetic expression.

Learning Objectives:

  • Review DNA methylation and its importance to aging and healthspan
  • Discuss the wide range of factors that influence methylation status
  • Provide practical assessment and intervention tools to support balanced methylation, including supplements, diet, and lifestyle
  • Learn what's next in assessing the methylome in clinical practice

Kara Fitzgerald, ND Kara Fitzgerald, ND

Kara Fitzgerald, ND, received her doctor of naturopathic medicine degree from the National University of Natural Medicine in Portland, Oregon. She completed the first Counsel on Naturopathic Medicine-accredited post-doctorate position in nutritional biochemistry and laboratory science at Metametrix Clinical Laboratory (now Genova Diagnostics) under the direction of Richard Lord, PhD. Her residency was completed at Progressive Medical Center, a large, integrative medical practice in Atlanta, Georgia.

Dr. Fitzgerald is the lead author and editor of Case Studies in Integrative and Functional Medicine and is a contributing author to Laboratory Evaluations for Integrative and Functional Medicine and the Institute for Functional Medicine (IFM)'s Textbook for Functional Medicine. Most recently, with Romilly Hodges, she authored the eBook The Methylation Diet and Lifestyle. Dr. Fitzgerald is actively engaged in clinical research on the methylome using diet and lifestyle interventions in conjunction with Helfgott Research Institute. She is a research clinician for The Institute for Therapeutic Discovery. Dr. Fitzgerald is on the faculty at IFM, is an IFM Certified Practitioner and lectures globally on functional medicine. She runs a Functional Medicine Clinic Immersion program for professionals, and maintains a podcast series, New Frontiers in Functional Medicine and an active blog on her website, Her clinical practice is in Sandy Hook, Connecticut.