PCBs Profile - Serum

The Polychlorinated Biphenyls (PCBs) Profile can help identify which of the most toxic PCBs a patient has been exposed to and the body burden of the patient. We look at the most commonly found PCBs, which have national reference ranges, that have been documented to cause adverse health problems. Levels are given both in parts per million (PPM) and as lipid-adjusted amounts so the clinician can best estimate the total body burden of these compounds.

Why perform polychlorinated biphenyl testing?

Once PCBs enter the body, they are absorbed by our fat cells and stored. Since PCBs are not water-soluble, they are not excreted from the body and accumulate over a person's lifetime, increasing that person's body burden of PCBs. Polychlorinated biphenyl testing can help you determine the extent of this PCB burden.

In adults, a heavy burden of PCBs over time can cause impairments in the brain, nervous system, endocrine system, and immune system, and may cause fertility issues.

A PCB burden affects children more than adults. PCBs are most often passed to children through breastfeeding and trans-placental transfer. PCB exposure in children can impede neurobehavioral and immune system development. These impediments may cause delayed neurobehavioral development in motor skills and short term memory, and lower scores on intelligence, psychomotor, and behavioral tests. A lowered immune system can create many problems in children including allergies, sensitivities, and chronic infections.

What are PCBs?

PCBs were used as lubricants and coolants in transformers, capacitors, and electronic equipment because of a high resistance to heat. Due to the stability of PCBs, unfortunately they also do not break down in the environment and bioaccumulate in animals and humans.

PCBs were banned from use in the US in 1979 by the Environmental Protection Agency (EPA). However, due to the persistence of PCBs in the environment, PCBs continue to leach into soil and groundwater from hazardous waste sites and landfills. Since PCBs bioaccumulate, we are exposed through our food chain by eating fish, meat, and dairy products, especially from areas of the country considered contaminated.

Symptoms of PCB exposure:

  • Severe acne
  • Rash
  • Eye irritation
  • Liver damage
  • Weakened immune system
  • Chemical sensitivity
  • Allergies
  • Obesity
  • Fatigue
  • Certain cancers
  • Developmental disorders

Test name(s):

0761 - Polychlorinated Biphenyls (PCBs) Profile*

Method: Gas Chromatography/Mass Spectrometry

*Not available in New York

Analyte List
PCB 118
PCB 126
PCB 138
PCB 153
PCB 156
PCB 169
PCB 180
PCB 74
PCB 77
CPT Codes  
Specimen Requirements
Serum, 8 ml, refrigerated, non-fasting,
Whole Blood, 14ml, refrigerated, non-fasting