CV Health Plus Genomics™

Assess Cardiovascular Risk with Advanced Lipid and Genomic Markers

Proceed to Clinical Overview

Why Use the CV Health Plus Genomics Profile?

CV Health Plus Genomics is a cardiovascular risk assessment that analyzes lipid biomarkers and genomic risk factors associated with cardiovascular disease (CVD). Traditional lipid markers (such as LDL/HDL cholesterol and triglycerides) while informative, do not fully account for individual cardiovascular risk

The CV Health Plus Genomics test assesses a combination of standard lipid markers and advanced biomarkers that provide information on cholesterol metabolism, inflammation, and insulin resistance. In addition, CV Health Plus Genomics analyzes for single nucleotide polymorphisms (SNPs) in four select genes related to cardiovascular health and blood clotting. With this genomic insight and biomarker information, clinicians can create highly personalized, targeted treatments that address specific metabolic areas to help minimize risk and support improved cardiovascular health.

Effective for Patients Experiencing:

CV Health Plus Genomics can help clinicians identify individuals at risk for cardiovascular disease and allow for monitoring of previously abnormal results.

CV Health Profile is appropriate for patients who:

  • Have a family history of heart disease
  • Are experiencing premature cardiovascular disease
  • Have abnormal serum lipids
  • Suffer from obesity and/or diabetes
  • Smoke
  • Are physically inactive

About the CV Health Plus Genomics Profile

Using color-coded graphics, the CV Health Plus Genomics report synthesizes test results into an easy-to-interpret reporting format. Genomic results are reported with accompanying information on health implications and treatment options.

CV Health Plus Genomics offers an innovative assessment featuring an advanced lipid profile using Nuclear Magnetic Resonance (NMR) fractionation technology, inflammatory markers, and a novel Insulin Resistance Score. In addition, this profile includes analyses for single nucleotide polymorphisms (SNPs) in four select genes related to cardiovascular health and blood coagulation.


Clinical Overview

What Are the CV Health Profiles (CV Health or CV Health plus Genomics)?

The CV Health Profiles are comprehensive evaluations of cardiovascular biomarkers featuring an advanced lipid profile that utilizes Nuclear Magnetic Resonance (NMR) fractionation technology, inflammatory biomarkers, and a novel Insulin Resistance Score. Both CV Health profiles evaluate:

  • Lipid Markers
    • LDL, HDL, Total Cholesterol, Triglycerides
    • LDL – Particle Number and Size
    • HDL – Particle Number and Size
    • Lp(a)
  • Independent Risk Factors
    • High Sensitivity CRP (hs-CRP)
    • Lp-PLA2 (PLAC)
    • Fibrinogen
    • Homocysteine
  • Insulin Resistance Score by Lipid Fractionation, combining:
    • Small LDL – Particle Number
    • LDL Size
    • Large VLDL – Particle Number
    • VLDL Size
    • Large HDL – Particle Number
    • HDL Size

CV Health Plus Genomics offers all biomarkers listed above from the original CV Health profile plus the addition of analyses for single nucleotide polymorphisms (SNPs) in four select genes related to cardiovascular health and blood coagulation:

  • APOE – plays a key role in lipid metabolism by removing dietary cholesterol (chylomicrons and VLDL) from the bloodstream
  • MTHFR – a key enzyme in folate metabolism, a required cofactor in the remethylation of homocysteine to methionine
  • Factor II (Prothrombin) – converts to active form, thrombin, forming the essential part of a blood clot
  • Factor V (Leiden) – combines with Factor X to convert prothrombin to thrombin

When Should a CV Health Profile Be Considered?

The CV Health profiles address the clinical complexity of cardiovascular disease by providing a thorough assessment of cardiovascular health status for any individual, and particularly for those people with:

  • A family history of heart disease or stroke
  • Known cardiovascular disease and/or abnormal serum lipids
  • Associated risk factors including obesity, diabetes, poor dietary habits, sedentary lifestyle, and smoking

What Advantages Do the CV Health Profiles Offer Compared to Other Diagnostics?

Traditionally assessed risk factors do not fully account for the development of cardiovascular disease, the number one cause of death in the US. The CV Health profiles offer a comprehensive evaluation featuring an advanced lipid profile that utilizes Nuclear Magnetic Resonance (NMR) fractionation technology, inflammatory markers, and a novel Insulin Resistance Score. These advanced biomarkers provide insight into metabolic areas associated with CVD risk, significantly increasing diagnostic yield. In addition, the genomics option provides insight into genetic predispositions that may increase risk for the development of cardiovascular disease.

What Can Clinicians and Patients Expect from CV Health Profile Testing?

In contrast to standard markers for cardiovascular disease risk, a structured comprehensive evaluation panel to evaluate fractionated biomarkers and independent risk factors provides clinical utility by supporting insight into development of personalized treatments. Targeted therapeutic interventions addressing specific metabolic areas can help minimize risk and support improved cardiovascular health.

Analyte List
APOE
Factor 2 (prothrombin)
Factor 5 (Leiden)
Fibrinogen
HDL L
HDL Size
HDL-Cholesterol
HDL-Particle # (HDL-P)
Homocysteine
LDL S
LDL Size
LDL-Cholesterol
LDL-Particle # (LDL-P)
Lipid Panel
Lp(a)
Lp-PLA2 (PLAC)
MTHFR
Triglycerides
VLDL L
VLDL Size
Vitamin D
hs C-Reactive Protein (hs-CRP)
CPT Codes  
APOE 83896, 83908, 83912
Factor 2 (prothrombin) 83896, 83908, 83912
Factor 5 (Leiden) 83896, 83908, 83912
Fibrinogen 85385
Homocysteine 83090
LDL S 83704
Lipid Panel 80061
Lp(a) 83695
Lp-PLA2 (PLAC) 83698
MTHFR 83896, 83908, 83912
Vitamin D 82306
hs C-Reactive Protein (hs-CRP) 86141
Specimen Requirements
Two 4 ml serum, 3 ml plasma, 2 buccal swabs, and 5 ml Z-serum separator, fasting