TRIAD® Profile - Blood & Urine

A Combination Nutritional Test Assessing Three Key Metabolic Areas

Featuring an Expanded Food Antibody Panel

Proceed to Clinical Overview


Why Use the TRIAD® Profile – Blood & Urine?

The TRIAD® Profile – Blood & Urine is a nutritional test that combines three key tests into one diagnostic solution. Imbalances or dysfunction in several metabolic areas can have overlapping and wide-ranging effects on health and play a causative role in many chronic conditions.

The Triad Profile – Blood & Urine assesses amino acids, organic acids, and IgG4 food antibodies and can provide guidelines for customized supplementation and dietary modification to improve health outcomes.

Clinical indications for testing include:

  • Food Sensitivities
  • Mood Disorders
  • Fatigue
  • Digestive Complaints
  • Weight Issues/Dietary Guidance

About the TRIAD Profile – Blood & Urine

Using a central blood draw and in-home overnight urine collection, the TRIAD Profile – Blood & Urine assesses an expanded menu of foods for those patients with suspected complex food sensitivities.

The complete TRIAD Profile – Blood & Urine assesses:

  1. IgG4 Food Antibodies 90 Profile (serum) – measures "delayed" reactions to 90 common foods
  2. 20 Amino Acids (plasma) – essential, conditionally essential, and non-essential amino acids, and key amino-acid ratios
  3. Organic Acids (urine) – nutrient markers, cell regulation markers, toxicants and detoxification markers, and compounds of bacterial or yeast/fungal origin

The distinctive TRIAD report offers multiple user-friendly features including:

  • A Customized Vitamin and Mineral Formulation – personalized nutrient recommendations based on test results
  • A Customized Amino Acid Formulation – supplemental amino acid formula based on test results

Clinical Overview

What Are the TRIAD® Profiles?

TRIAD® Profile – Blood & Urine or TRIAD® Bloodspot

As the name indicates, the TRIAD nutritional test integrates three informative nutritional tests into a single innovative profile. Available with either a central blood draw or a finger-stick bloodspot collection, both TRIAD profiles include:

  1. IgG4 Food Antibodies – measures "delayed" sensitivity reactions to common foods; either 90 foods (TRIAD Blood & Urine) or 30 foods (TRIAD Bloodspot)

  2. Organic Acids (urine)
    • Nutrient Markers
      • Fatty Acid Metabolism
      • Carbohydrate Metabolism
      • Energy Production (Citric Acid Cycle)
      • B-Complex Vitamin Markers
      • Methylation Cofactor Markers
    • Cell Regulation Markers
      • Neurotransmitter Metabolism Markers
      • Oxidative Damage and Antioxidant Markers
    • Toxicants and Detoxification
      • Detoxification Indicators
    • Compounds of Bacterial or Yeast/Fungal Origin
      • Bacterial – General
      • L. acidophilus/General Bacterial
      • Clostridial Species
      • Yeast/Fungal

  3. 20 Amino Acids (plasma [TRIAD Blood & Urine] or bloodspot [TRIAD Bloodspot]) – essential, conditionally essential, and non-essential amino acids, reported in clinically useful categories:
    • Essential Amino Acids
      • Limiting Amino Acids
      • Branched Chain Amino Acids
      • Other Essential Amino Acids
      • Conditionally Essential Amino Acids
    • Amino Acid Functional Categories
      • Vascular Function
      • Neurotransmitters and Precursors
      • Sulfur Amino Acids (Glutathione-related)
      • Urea Cycle and Ammonia Detoxification
      • Ratios

The distinctive TRIAD report provides:

  • Summary of Abnormal Results – organizes abnormal findings into functional categories to enhance clinical utility
  • Analyte Pattern Analysis – organizes analyte results into categories associated with clinical/metabolic conditions
  • Customized Vitamin and Mineral Formulation – personalized nutrient recommendations based on test results
  • Customized Amino Acid Formulation – customized free-form amino acids formulation based on test results

When Should a TRIAD Profile be Considered?

Patients with chronic symptoms may benefit from assessment of (1) reactivity to regularly eaten foods that may be producing chronic symptoms, but which are unsuspected due to a delay in onset of symptoms after consumption of offending food, (2) urine organic acids to evaluate specific metabolic pathways and biomarkers of enzyme vitamin and mineral cofactor need, and (3) amino acids in blood to assess protein status and utilization.

Clinical indications for testing include:

  • Food Sensitivities
  • Mood Disorders
  • Fatigue
  • Digestive Complaints
  • Weight Issues/Dietary Guidance

What Advantage Do the TRIAD Profiles Offer Compared to Other Diagnostics?

The TRIAD profiles allow simultaneous assessment of key biomarkers in three areas of metabolism. Imbalances or dysfunction in these areas can have over-lapping and wide-ranging effects on overall health and can play a causative role in many chronic conditions.

The TRIAD report provides an Analyte Pattern Analysis, which organizes analyte results into categories associated with clinical/metabolic conditions. Patterns of abnormalities can reinforce the degree of significance indicated by a single measurement. The TRIAD report also includes personalized intervention guidelines featuring a custom vitamin/mineral formula and a custom amino acid blend.

What Can Clinicians and Patients Expect from TRIAD Testing?

Results from organic acids, amino acids, and IgG4 food antibody testing can indicate the functional need for specific nutrients, dietary modification, antioxidant protection, detoxification, and other therapies. These tools can assist the clinician in making tailored therapeutic recommendations, which may also enhance the effectiveness of other treatments, improving overall health outcomes and the patient's ability to combat chronic illness.

There are two TRIAD nutritional tests available to meet specific clinical needs:

  • TRIAD Profile – Blood & Urine – uses a central blood draw and in-home overnight urine collection; offers a 90-food panel for IgG4 testing
  • TRIAD Bloodspot – uses in-home finger-stick bloodspot collection (a suitable option for clinicians without access to blood-draw facilities) and in-home overnight urine collection; offers a 30-food panel for IgG4 food antibody testing

Test name(s): 0400 - TRIAD® Profile*

Method: LC/MS-MS, HPLC, Spectrophotometry, EIA

*Not Available in New York

Test Type: Blood & Urine Test

Analyte List
1-Methylhistidine
2-Methylhippurate
3,4 Dihydroxyphenylpropionate
3-Methylhistidine
5-hydroxyindoleacetate
8-Hydroxy-2'-deoxyguanosine*
Adipate
Alanine
Almond
Alpha-Amino-N-Butyric Acid
Alpha-Aminoadipic Acid
Alpha-Hydroxybutyrate
Alpha-Keto-Beta-Methylvalerate
Alpha-Ketoglutarate
Alpha-Ketoisocaproate
Alpha-Ketoisovalerate
Anserine
Apple
Apricot
Arginine
Asparagine
Asparagus
Aspartic Acid
Aspergillus Mold
Avocado
Banana
Barley
Bean, String
Beef
Benzoate
Beta-Alanine
Beta-Aminoisobutyric Acid
Beta-Hydroxybutyrate
Beta-Hydroxyisovalerate
Black Pepper
Blueberry
Broccoli
Cabbage
Cantaloupe
Carnosine
Carrot
Casein
Cashew
Cauliflower
Celery
Chicken
Chocolate
Cinnamon
Citrate
Citrulline
Clam
Coconut
Codfish
Coffee
Corn
Crab
Cranberry
Creatinine
Cucumber
Cystahionine
Cystine
D-Arabinitol*
D-Lactate*
Egg White
Egg Yolk
Ethanolamine
Ethylmalonate
Flounder
Formiminoglutamate
Fumarate
Gamma-aminobutyric acid
Garlic
Ginger
Glucarate
Glutamic acid
Glutamine
Glycine
Grape
Grapefruit
Halibut
Hippurate
Histidine
Homocystine
Homvanillate
Honeydew
Hydroxylysine
Hydroxymethylglutarate
Indican
Isocitrate
Isoleucine
Kynurenate
L-Lactate*
Lamb
Lemon
Lentil
Lettuce
Leucine
Lima Bean
Lobster
Lysine
Mackerel
Malate
Malt
Methionine
Methylmalonate
Milk
Mushroom
Mustard Seed
Navy Bean
Oat
Olive
Onion
Orange
Ornithine
Orotate
Oyster
Pea, Green
Peach
Peanut
Pear
Pecan
Pepper, Green
Phenylacetate
Phenylalanine
Phenylpropionate
Phosphoethanolamine
Phosphoserine
Picolinate*
Pineapple
Pinto Bean
Pistachio
Pork
Potato
Proline
Pyroglutamate
Pyruvate
Quinolinate
Rice
Rye
Salmon
Sarcosine
Serine
Sesame
Shrimp
Soybean
Spinach
Strawberry
Suberate
Succinate
Sulfate
Sunflower
Sweet Potato
Taurine
Tea
Threonine
Tomato
Tricarballylate
Trout
Tryptophan
Tuna
Turkey
Tyrosine
Valine
Vanilla
Vanilmandelate
Walnut, English
Watermelon
Wheat
Xanthurenate
Yeast, Baker's
Yeast, Brewer's
Zucchini
cis-Aconitate
p-Hydroxybenzoate
p-Hydroxyphenylacetate
p-Hydroxyphenyllactate
CPT Codes  
1-Methylhistidine 82139
3-Methylhistidine 82139
Alanine 82139
Almond 86001
Alpha-Amino-N-Butyric Acid 82139
Alpha-Aminoadipic Acid 82139
Anserine 82139
Apple 86001
Apricot 86001
Arginine 82139
Asparagine 82139
Asparagus 86001
Aspartic Acid 82139
Aspergillus Mold 86001
Avocado 86001
Banana 86001
Barley 86001
Bean, String 86001
Beef 86001
Beta-Alanine 82139
Beta-Aminoisobutyric Acid 82139
Black Pepper 86001
Blueberry 86001
Broccoli 86001
Cabbage 86001
Cantaloupe 86001
Carnosine 82139
Carrot 86001
Casein 86001
Cashew 86001
Cauliflower 86001
Celery 86001
Chicken 86001
Chocolate 86001
Cinnamon 86001
Citrulline 82139
Clam 86001
Coconut 86001
Codfish 86001
Coffee 86001
Corn 86001
Crab 86001
Cranberry 86001
Cucumber 86001
Cystahionine 82139
Cystine 82139
Egg White 86001
Egg Yolk 86001
Ethanolamine 82139
Flounder 86001
Gamma-aminobutyric acid 82139
Garlic 86001
Ginger 86001
Glutamic acid 82139
Glutamine 82139
Glycine 82139
Grape 86001
Grapefruit 86001
Halibut 86001
Histidine 82139
Homocystine 82139
Honeydew 86001
Hydroxylysine 82139
Isoleucine 82139
Lamb 86001
Lemon 86001
Lentil 86001
Lettuce 86001
Leucine 82139
Lima Bean 86001
Lobster 86001
Lysine 82139
Mackerel 86001
Malt 86001
Methionine 82139
Milk 86001
Mushroom 86001
Mustard Seed 86001
Navy Bean 86001
Oat 86001
Olive 86001
Onion 86001
Orange 86001
Ornithine 82139
Oyster 86001
Pea, Green 86001
Peach 86001
Peanut 86001
Pear 86001
Pecan 86001
Pepper, Green 86001
Phenylalanine 82139
Phosphoethanolamine 82139
Phosphoserine 82139
Pineapple 86001
Pinto Bean 86001
Pistachio 86001
Pork 86001
Potato 86001
Proline 82139
Rice 86001
Rye 86001
Salmon 86001
Sarcosine 82139
Serine 82139
Sesame 86001
Shrimp 86001
Soybean 86001
Spinach 86001
Strawberry 86001
Sunflower 86001
Sweet Potato 86001
Taurine 82139
Tea 86001
Threonine 82139
Tomato 86001
Trout 86001
Tryptophan 82139
Tuna 86001
Turkey 86001
Tyrosine 82139
Valine 82139
Vanilla 86001
Walnut, English 86001
Watermelon 86001
Wheat 86001
Yeast, Baker's 86001
Yeast, Brewer's 86001
Zucchini 86001
Specimen Requirements
Serum, 3 ml, refrigerated
Plasma, 2.5-3 ml, frozen
Overnight Urine, 12 ml, frozen