Organix® Dysbiosis Profile - Urine

The Russian scientist Elie Metchnikoff (1845 - 1916) popularized the idea of "Dys-symbiosis" or "Dysbiosis," describing an imbalance in the microecology of the digestive tract. When the microbial balance of the gut is disturbed, opportunistic, or "bad", bacteria can overgrow and mitigate the effects of the "good", predominant bacteria needed for a healthy gut.

Advantages of the Organix® Dysbiosis Profile

  • Reports D-arabinitol, a specific marker for Candida sp., which can cause disease in patients, especially if they are immunocompromised.
  • Reports D-lactate, an indicator of L. acidophilus overgrowth and carbohydrate malabsorption.
  • Utilizes the LC/MS-MS method, providing more stability, accuracy, and sensitivity in measuring organic acids at low levels for optimum test results.
  • A single urine specimen is easy for patients, leading to increased patient compliance.
  • Discrimination between microbial classes allows for more focused and targeted therapies.
  • An economical follow-up test for practitioners to monitor targeted therapy.

Why use the Organix® Dysbiosis Profile?

The Organix® Dysbiosis Profile is a urine organic acid test measuring the by-products of microbial metabolism, and is particularly useful in detecting the presence of pathogenic microbial overgrowth. As a stand-alone test, the Organix® Dysbiosis Profile is a great follow-up option to the Organix® Comprehensive Profile, allowing the clinician to assess microbial overgrowth and guide and monitor targeted therapy in patients.

Is Urine Organic Acid Testing Useful for Assessing Dysbiosis?

Urine contains unique products of microbial metabolism which are used to measure small bowel yeast and bacterial overgrowth. With the exception of hippurate, the compounds measured in the Organix® Dysbiosis Profile, such as D-arabinitol, are not normally produced by human cells. Unfriendly intestinal microorganisms, however, can manufacture them in relatively high quantities. These compounds are absorbed into the blood from the intestines and eventually appear in a urine organic acid test.

Stool testing also gives insight into the gut microbial population of the large bowel.

The Organix Dysbiosis Profile and the GI Effects Stool Profile can be utilized together to gain an overall snapshot of a patient's gut health.

Symptoms of dysbiosis can be as diverse as:

  • Behavioral disorders
  • Chronic fatigue
  • Depression
  • Headache
  • Immune dysfunction
  • Insomnia
  • Irritable Bowel Syndrome (IBS)
  • Joint pain
  • Learning disorders
  • Nutritional deficiencies
  • Food allergies
  • Skin disorders, acne

Test name(s):

  • 0097 - Organix Dysbiosis Profile*
  • 0397 - Organix Compounds of Microbial Origin Profile NY

Method: LC/MS-MS Tandem Mass Spectrometry

*Not available in New York

Test Type: Urine Test

Analyte List
3,4 Dihydroxyphenylpropionate
Benzoate
Creatinine
D-Arabinitol
D-Lactate*
Hippurate
Indican
Phenylacetate
Phenylpropionate
Tricarballylate
p-Hydroxybenzoate
p-Hydroxyphenylacetate
CPT Codes  
Specimen Requirements
Overnight Urine, 12 ml, frozen